Buy Lotrisone (Betamethasone Dipropionate, Clotrimazole) antifungal drug
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LOTRISONE (BETAMETHASONE DIPROPIONATE, CLOTRIMAZOLE) CREAM AND LOTION: PRESCRIBING INFORMATION
Lotrisone cream and lotion contain combinations of clotrimazole, a synthetic antifungal agent, and betamethasone dipropionate, a synthetic corticosteroid, for dermatologic use.
Chemically, clotrimazole is 1-(o-chloro-alpha,alpha-diphenylbenzyl) imidazole, with the empirical formula C22H17CIN2, a molecular weight of 344.84.
Clotrimazole is an odorless, white crystalline powder, insoluble in water and soluble in ethanol.
Betamethasone Dipropionate has the chemical name 9-fluoro-11-beta,17,21trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate, with the empirical formula C28H37FO7, a molecular weight of 504.59.
Betamethasone Dipropionate is a white to creamy white, odorless crystalline powder, insoluble in water.
Each gram of Lotrisone cream contains 10 mg clotrimazole and 0.643 mg betamethasone dipropionate (equivalent to 0.5 mg betamethasone), in a hydrophilic cream consisting of purified water, white petrolatum, mineral oil, cetyl alcohol plus stearyl alcohol, propylene glycol, ceteareth-30, sodium phosphate monobasic monohydrate, and phosphoric acid; benzyl alcohol as preservative.
Lotrisone cream may contain sodium hydroxide. Lotrisone cream is smooth, uniform, and white to off-white in color.
Each gram of Lotrisone lotion contains 10 mg clotrimazole and 0.643 mg betamethasone dipropionate (equivalent to 0.5 mg betamethasone), in a hydrophilic base of purified water, mineral oil, cetyl alcohol plus stearyl alcohol, white petrolatum, ceteareth-30, sodium phosphate monobasic monohydrate, propylene glycol, and phosphoric acid; benzyl alcohol as a preservative.
Lotrisone lotion may contain sodium hydroxide. Lotrisone lotion is opaque and white in color.
Lotrisone cream and lotion clinical pharmacology
Lotrisone cream and lotion microbiology
Lotrisone cream and lotion pharmacokinetics
Lotrisone cream and lotion clinical studies
INDICATIONS AND USAGE
Lotrisone cream and lotion are indicated in patients 17 years and older for the topical treatment of symptomatic inflammatory tinea pedis, tinea cruris, and tinea corporis due to Epidermophyton floccosum, Trichophyton mentagrophytes, and Trichophyton rubrum. Effective treatment without the risks associated with topical corticosteroid use may be obtained using a topical antifungal agent that does not contain a corticosteroid, especially for noninflammatory tinea infections. The efficacy of Lotrisone cream and lotion (Betamethasone, Clotrimazole) for the treatment of infections caused by zoophilic dermatophytes (eg, Microsporum canis) has not been established. Several cases of treatment failure of Lotrisone cream in the treatment of infections caused by Microsporum canis have been reported.
Lotrisone cream or lotion is contraindicated in patients who are sensitive to clotrimazole, betamethasone dipropionate, other corticosteroids or imidazoles, or to any ingredient in these preparations.
Lotrisone cream and lotion precautions
Lotrisone cream and lotion nonclinical toxicology
USE IN PREGNANCY
Lotrisone cream and lotion use in pregnancy
USE IN SPECIFIC POPULATIONS
Lotrisone cream and lotion use in specific populations
Lotrisone cream and lotion adverse reactions
Amounts greater than 45 g/week of Lotrisone cream or 45 mL/week of Lotrisone lotion should not be used. Acute overdosage with topical application of Lotrisone (Betamethasone, Clotrimazole) cream and lotion is unlikely and would not be expected to lead to a life-threatening situation. Lotrisone cream or lotion should not be used for longer than the prescribed time period.
Topically applied corticosteroids, such as the one contained in Lotrisone cream or lotion can be absorbed in sufficient amounts to produce systemic effects.
DOSAGE AND ADMINISTRATION
Lotrisone cream and lotion dosage and administration
Lotrisone cream is supplied in 15-g and 45-g tubes; boxes of one. Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F) [see USP Controlled Room Temperature].
Lotrisone lotion is supplied in 30-mL bottles, box of one. Store at 25°C (77°F) in the upright position only; excursions permitted between 15°C and 30°C (59°F and 86°F).
Shake lotion well before each use.
Manufactured and distributed by Merck, Schering-Plough pharmaceutical companies and their divisions.
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